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LDL-Cholesterol Direct Early detection of cardiovascular disease risk & monitoring of cholesterol levels LDL-cholesterol Direct testing measures the amount of LDL cholesterol in a sample of blood directly using sandwich immunodetection method. LDL cholesterol is known as a type of “bad” cholesterol because it can build up in the blood vessels such as arteries and increase the risk of stroke, heart disease, and heart attack. Accessing LDL cholesterol levels can be involved in screening of cardiovascular disease risk, monitoring to assess cardiovascular health and to see if treatment to lower LDL cholesterol has been effective.